Miconazole vaginal suppositories 100mg №7x1

Name: Miconazole supp vag 100mg in a cell. pack No. 7x1 Description: Suppositories are cylindrical in shape, white or white with a yellowish tint. On the cut, the presence of an air and porous rod and a funnel-shaped recess is allowed. The main active ingredient Miconazole Release form Suppositories Dosage 100 mg Pharmacological action Antiseptics and antimicrobials for the treatment of gynecological diseases (excluding combinations with corticosteroids). imidazole derivatives. ATX code: G01AF04. Pharmacodynamics Miconazole is a synthetic antifungal agent derived from imidazole. It has antifungal and antibacterial action. The most sensitive to miconazole are dermatomycetes and yeasts. It is active against the causative agent of multi-colored lichen (Malassezia furfur), pathogens of some dermatomycosis (Candida albicans, Trichophyton, Epidermophyton floccosum, Microsporum). Shows activity against Dimorphons fungi, Cryptococcus neoformans, Aspergillus spp., Pityrosporum, Torulopsis glabrata, Pseudallescheria boydii; some gram-positive microorganisms, including staphylococci and streptococci. The fungicidal and fungistatic effect of miconazole nitrate is due to the inhibition of ergosterol biosynthesis, changes in the lipid composition and permeability of the cell wall, which causes the death of the fungal cell. Pharmacokinetics With intravaginal administration of miconazole nitrate, it is absorbed slightly and is not detected in plasma. Indications for use: vulvovaginal candidiasis; superinfection caused by gram-positive microorganisms. If you need more information about your condition, ask your doctor for advice. Method of administration and doses The use of this medicinal product is possible only after consulting a doctor! Do not stop taking Miconazole without first consulting your doctor! If you have any doubts or questions, please contact your doctor. For vaginal use. 1 suppository (100 mg) once a day, in the evening before bedtime for 7-14 days, or one suppository in the morning and evening for 7 days. The suppository is released from the contour packaging, after cutting the film along the contour of the suppository with scissors, it is inserted as deep as possible into the vagina, in the supine position. Use during pregnancy and lactation If you are pregnant or breastfeeding, if you suspect that you are pregnant or do not rule out the possibility of pregnancy, tell your doctor about it. The drug is contraindicated for use in the first trimester of pregnancy. In the II and III trimesters of pregnancy, the drug can be used only in cases where the expected benefit to the woman outweighs the potential risk to the fetus. Caution should be exercised when using the drug during lactation. Precautions With caution prescribed for diabetes mellitus, impaired microcirculation. The use of suppositories can reduce the reliability of mechanical contraception (condoms, vaginal diaphragms) due to the interaction of the suppository base with latex or rubber. If there is an infection in the sexual partner, appropriate treatment should be prescribed. The appearance of allergic reactions or the absence of clinical improvement within 7 days requires discontinuation of treatment and additional examination. If necessary, the drug can be removed by washing the vagina with boiled water. Serious hypersensitivity reactions, including anaphylaxis and angioedema, have been reported with other miconazole preparations. If hypersensitivity reactions or irritation occur during treatment, treatment should be discontinued. Use of the drug in children Not recommended for use in children and adolescents under the age of 18 due to lack of data on efficacy and safety. Use in persons with impaired renal function: no features. Application in geriatric practice: without features. Interaction with other drugs If you are currently or have recently taken other drugs, tell your doctor. Miconazole increases the effectiveness of indirect anticoagulants for oral administration, hypoglycemic agents, sulfonylurea derivatives, phenytoin. Rifampicin weakens the therapeutic effect of miconazole, and their combined use should be avoided. With simultaneous use with carbamazepine, the risk of side effects increases. With simultaneous use with astemizole, cisapride, terfenadine, the risk of developing arrhythmias increases. Due to the limited systemic availability of miconazole after vaginal administration, clinically significant interactions are very rare. Therapeutic effects and adverse reactions of drugs metabolized by CYP2C9 (eg, oral hypoglycemic agents and phenytoin) and CYP3A4 (eg, HMG-CoA reductases such as simvastatin and lovastatin and calcium channel blockers such as dihydropyridines and verapamil) co-administration with miconazole may increase, so caution should be exercised. Contraindications Hypersensitivity to miconazole and other imidazole derivatives; severe liver dysfunction; first trimester of pregnancy; age up to 18 years, the use of virgins. Composition 1 suppository contains: active substance: miconazole nitrate 100 mg; excipients: solid fat. Overdose Due to the low absorption of the drug, an overdose with intravaginal use is unlikely. In case of accidental ingestion, no problems are expected. When swallowing a large amount of the drug, if necessary, gastric lavage is performed. Adverse reactions If side effects occur, tell your doctor about it. This applies to all possible side effects, including those not described in this package insert. MedDRA convention for frequency Very common (≥1/10); frequent (?1/100, <1/10); infrequent (?1/1000, <1/100); rare (?1/10000, <1/1000); very rare (<1/10000), with an unknown frequency (cannot be estimated from the available data). General disorders and disorders at the injection site: rare - especially at the beginning of treatment, local irritation of the vaginal mucosa, itching, burning sensation, rash, itchy rash, dysmenorrhea are possible. Storage conditionsStore in a dry, dark place at a temperature not exceeding 25 °C. Do not freeze. Buy Miconazole vaginal suppositories 100mg №7x1 Price for Miconazole vaginal suppositories 100mg №7x1