Relief rectal ointment 2.5mg/g 28.4g №1

Name: Relief. Description: Yellow ointment without foreign substances with a slight characteristic odor. The main active ingredient is shark liver oil + phenylephrine. Release form Rectal ointment. Pharmacological propertiesPhenylephrine hydrochloride is an alpha-agonist, has a local vasoconstrictor effect, which helps to reduce exudation, tissue swelling, and itching in the anorectal region. Indications for use As a symptomatic remedy for hemorrhoids, anal fissures, anal itching. Dosage and administration Use the drug after hygiene procedures. Remove the protective cap from the applicator. Attach the applicator to the tube and squeeze out a small amount of ointment to lubricate the applicator. Apply the ointment carefully through the applicator to the affected areas outside or inside the anus up to 4 times a day (in the morning, at night and after each bowel movement). Rinse the applicator thoroughly after each use and place it in the protective cap. Children under 12 years old - as prescribed by a doctor. The dose used for self-treatment of hemorrhoids in adults and children over 12 years of age should not exceed 2 mg of phenylephrine hydrochloride (1 g of ointment contains 2.5 mg of phenylephrine hydrochloride) per day. It is not recommended to exceed the indicated dose without a doctor's prescription. Use during pregnancy and lactation The drug is not recommended for use during pregnancy and lactation. Influence on the ability to drive vehicles and work with mechanisms It is recommended to be careful due to the possible development of adverse reactions from the nervous system. Precautions for patients with arterial hypertension, cardiovascular disease, thyroid disease, angle-closure glaucoma, diabetes mellitus, liver disease, pancreas, urination disorders (for example, in the case of prostatic hyperplasia), the drug can be used only after consulting a doctor, during treatment medical supervision is necessary. Before prescribing the drug, the doctor should clarify the allergic history, including allergic reactions to other sympathomimetic drugs. In case of heavy bloody discharge from the anus or the absence of a therapeutic effect when using the drug, you should consult a doctor. Interaction with other drugs The drug should not be used simultaneously with other vasoconstrictors (regardless of the route of administration of the latter), as well as with antihypertensive drugs (13-blockers). Atropine sulfate blocks the reflex bradycardia caused by phenylephrine and increases the vasopressor response to phenylephrine. The simultaneous use of phenylephrine with B-blockers can lead to arterial hypertension and severe bradycardia with possible heart block. Caution should be exercised when using Relief together with thyroid hormones, drugs that affect cardiac conduction (cardiac glycosides, antiarrhythmic drugs). When used simultaneously with drugs that cause potassium excretion (for example, with diuretics such as furosemide), hypokalemia may increase and sensitivity to vasopressor drugs such as phenylephrine may decrease. The simultaneous use of phenylephrine and other sympathomimetic drugs can lead to additional stimulation of the central nervous system, which is accompanied by agitation, irritability, insomnia, and a seizure may develop. Relief should not be used simultaneously or within 14 days after stopping treatment with MAO inhibitors. Contraindications Hypersensitivity to the components of the drug, severe arterial hypertension, tachysystolic cardiac arrhythmias, decompensated heart failure, cardiac conduction disorders, severe renal and / or liver failure, thyrotoxicosis, acute pancreatitis, thromboembolism (including previously transferred), granulocytopenia, simultaneous use with monoamine oxidase (MAO) inhibitors or within 14 days after stopping treatment with MAO inhibitors. Composition Active ingredient: phenylephrine hydrochloride 2.5 mg/g. Excipients: mineral oil, petrolatum, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), anhydrous lanolin, benzoic acid (E210), corn oil, glycerol, lanolin alcohols, solid paraffin (58/60), thyme oil, vitamin E, white wax, purified water. Overdose In case of a significant excess of the recommended single and daily doses, there may be a tendency to hypercoagulability. In case of an overdose, the following disorders are possible: arterial hypertension, pain and discomfort in the heart area, palpitations, respiratory disorders, non-cardiogenic pulmonary edema, agitation, convulsions, sleep disturbances, anxiety, irritability, psychoses with hallucinations, general weakness, anorexia, nausea, vomiting, oliguria, urination disorders, redness of the face, feeling of coldness in the extremities, paresthesia, hyperglycemia, hypokalemia, decreased blood flow to vital organs, which can lead to poor blood supply to the kidneys, metabolic acidosis, increased load on the heart due to an increase in total peripheral resistance. Treatment is symptomatic. Side effects The following adverse reactions are possible: From the side of the cardiovascular system: reflex bradycardia, cardiac arrhythmias, increased blood pressure. On the part of the immune system: hypersensitivity reactions, including cross-type reactions in case of allergic reactions to other sympathomimetic drugs, which can manifest as skin rash, itching, angioedema, contact dermatitis. From the nervous system: dizziness, nervousness, headache, tremor, insomnia, anxiety, feeling hot flashes. From the skin and subcutaneous tissues: contact dermatitis, hyperemia, skin rash, itching, swelling, pain, burning. Reporting Adverse Reactions If you experience any adverse reactions, please contact your physician. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the adverse drug reactions (actions) information database, including reports of drug failures. By reporting adverse reactions, you help to get more information about the safety of the drug. Storage conditions At a temperature not exceeding 25 ° C, out of the reach of children. 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